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Antidepressants help block certain neurotransmitters that can cause depression. While most antidepressants work well at balancing neurological chemicals that may cause depression, they can also cause impotence. For example SSRI drugs block the absorption or “reuptake” of serotonin, which is most related to depression. However, SSRI drugs can cause weight gain, dry mouth, restlessness, and impotence. Men (and women) who feel depressed should instead try all-natural solutions and herbs that can help eliminate bad thoughts and negative feelings.